When Laura Estreich is born, her appearance presents a puzzle: does the shape of her eyes indicate Down syndrome or the fact that she has a Japanese grandmother? In this powerful memoir, George Estreich, a poet and stay-at-home dad, tells his daughter's story, reflecting on her inheritance - from the literal legacy of her genes, to the family history that precedes her, to the Victorian physician John Langdon Down's diagnostic error of "Mongolian idiocy." Against this backdrop, Laura takes her place in the Estreich family as a unique child, quirky and real, loved for everything ordinary and extraordinary about her.